N EtOH affords the corresponding bicyclic system 29, bearing an amino group at position C4 [79].Pharmaceuticals 2021, 14,Scheme 4 shows the usage of 4-aminonicotinonitrile (27) within the formation with the 1,6Scheme 4 shows the use of 4-aminonicotinonitrile (27) within the formation in the 1,6Scheme four shows theIn this example, the condensation amongst formation from the 1,6Scheme four shows the use of 4-aminonicotinonitrile (27) within the 27 and diethyl malonaphthyridin-2(1H)-one. Within this instance, the condensation amongst formation from the 1,6naphthyridin-2(1H)-one. use of 4-aminonicotinonitrile (27) in the 27 and diethyl malonaphthyridin-2(1H)-one. In this example, the condensation in between 27 and diethyl malonaphthyridin-2(1H)-one. Within this instance, corresponding bicyclic technique 29, bearing an nate (28) in NaOEt in EtOH affords the corresponding bicyclic program 29, bearing an nate (28) in NaOEt in EtOH affords the the condensation between 27 and diethyl malo9 of 15 nate (28) in NaOEt in EtOH affords the corresponding bicyclic technique 29, bearing an nate (28) in NaOEt in EtOH affords the corresponding bicyclic system 29, bearing an amino group at position C4 [79]. amino group at position C4 [79]. amino group at position C4 [79]. amino group at position C4 [79].Scheme 4. CFT8634 Technical Information Synthesis of 1,6-naphthyridin-2(1H)-one (29) from 4-aminonicotinonitrile (27). Scheme 4. Synthesis of 1,6-naphthyridin-2(1H)-one (29) from 4-aminonicotinonitrile (27). Scheme 4. Synthesis of 1,6-naphthyridin-2(1H)-one (29) from 4-aminonicotinonitrile (27). Scheme four. Synthesis of 1,6-naphthyridin-2(1H)-one (29) from 4-aminonicotinonitrile (27). Scheme 4. of 1,6-naphthyridin-2(1H)-one (29) from 4-aminonicotinonitrile (27).Similarly, the usage of 4-aminonicotinic acid (30), condensed with diethyl malonate Similarly, the use of 4-aminonicotinic acid (30), condensed with diethyl malonate Similarly, the use of 4-aminonicotinic acid (30), condensed with diethyl malonate Similarly, the use of 4-aminonicotinic acid (30), 1,6-naphthyridin-2(1H)-one 31 [47] (28), Similarly, the usage of 4-aminonicotinic acid (30), 1,6-naphthyridin-2(1H)-one 31 [47] affords the corresponding 4-hydroxy LY294002 Stem Cell/Wnt substituted condensed with diethyl malonate (28), affords the corresponding 4-hydroxy substituted condensed with diethyl malonate (28), affords the corresponding 4-hydroxy substituted 1,6-naphthyridin-2(1H)-one 31 [47] (28), affords the corresponding 4-hydroxy substituted 1,6-naphthyridin-2(1H)-one 31 [47] (28), affords (Scheme 5). (Scheme 5). the corresponding 4-hydroxy substituted 1,6-naphthyridin-2(1H)-one 31 [47] (Scheme 5). (Scheme five). (Scheme 5).Scheme 5. Synthesis of 1,6-naphthyridin-2(1H)-one (31) from 4-aminonicotinic acid (30). Scheme 5. Synthesis of 1,6-naphthyridin-2(1H)-one (31) from 4-aminonicotinic acid (30). Scheme five. Synthesis of 1,6-naphthyridin-2(1H)-one (31) from 4-aminonicotinic acid (30). Scheme 5. Synthesis of 1,6-naphthyridin-2(1H)-one (31) from 4-aminonicotinic acid (30). Scheme five. (31) from 4-aminonicotinic acid (30).Ultimately, there is a single instance from the use of this tactic for the synthesis of a 1,6Finally, there is a single instance from the use of of this technique for the synthesisaof a Finally, there is a single exampleof the use this method for the synthesis of 1,6is a single of your Finally, there’s a single instance C3-C4 use of [30]. approach for the synthesis of a 1,6Finally, there naphthyridin-2(1H)-one withexample C3-C4 use of[30]. strategy for the synthesis of a 1,6a single bond this nap.