Name : Mouse Hepcidin/HAMP Protein
Product Source :
Recombinant Mouse Hepcidin/HAMP Protein is expressed from E.coli with GST tag at the N-Terminus. It contains Asp59-Thr83.[Accession | Q9EQ21]
Molecular Weight :
The protein has a predicted MW of 29.05 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in 50mM Tris-HCl, 150mM NaCl, 2mM DTT (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse Hepcidin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
Synonyms :
Hamp1; Hepc; Hepc1; HFE2B; LEAP1; LEAP-1; PLTR
References & Citations :
Silvestri L, Nai A, Dulja A, Pagani A. Hepcidin and the BMP-SMAD pathway: An unexpected liaison. Vitam Horm. 2019;110:71-99. doi: 10.1016/bs.vh.2019.01.004. Epub 2019 Feb 10. PMID: 30798817.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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