Name : Human Hyaluronidase 2/HYAL2 Protein
Product Source :
Recombinant Human Hyaluronidase 2/HYAL2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Met21-Gly447.[Accession | Q12891]
Molecular Weight :
The protein has a predicted MW of 49.22 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Hyaluronidase 2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries.
Synonyms :
Hyaluronidase-2; Hyaluronidase 2; HYAL2; Hyal-2; LuCa-2; LUCA2; HYAL2
References & Citations :
(1) Cavallini M, Gazzola R, Metalla M, Vaienti L. The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. Aesthet Surg J. 2013 Nov 1;33(8):1167-74. doi: 10.1177/1090820X13511970. Epub 2013 Nov 6. PMID: 24197934.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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