Name : Human ICAM-3/CD50 Protein
Product Source :
Recombinant Human ICAM-3/CD50 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln30-His485.[Accession | CAA49369.1]
Molecular Weight :
The protein has a predicted MW of 50.54 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ICAM-3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
ICAM-3 interacts with LFA1, and is involved in the intercellular adhesion of leukocytes as well as in the mainenance of cell survival. ICAM-3 expression induces cancer cell proliferation, and an increase in ICAM-3 expression can contribute to cancer progression.
Synonyms :
Intercellular adhesion molecule 3; ICAM3; CDw50; ICAM-R; CD50
References & Citations :
Kim YG, Kim MJ, Lim JS, Lee MS, Kim JS, Yoo YD. ICAM-3-induced cancer cell proliferation through the PI3K/Akt pathway. Cancer Lett. 2006 Jul 28;239(1):103-10. doi: 10.1016/j.canlet.2005.07.023. Epub 2005 Aug 31. PMID: 16137825.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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