Name : Human IGF2R Domain 1-3 Protein

Product Source :
Recombinant Human IGF2R Domain 1-3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Glu47-Lys468.[Accession | P11717]

Molecular Weight :
The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human IGF2R Domain 1-3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human IGF2R Domain 1-3 is greater than 95% as determined by SEC-HPLC.

Background :
The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer.

Synonyms :
CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI

References & Citations :
Martin-Kleiner I, Gall Troselj K. Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis. Cancer Lett. 2010 Mar 1;289(1):11-22. doi: 10.1016/j.canlet.2009.06.036. Epub 2009 Jul 30. PMID: 19646808.

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