Name : Mouse IgG2C Protein
Product Source :
Recombinant Mouse IgG2C Protein is expressed from HEK293 without tag. It contains Ile97-Ser330.[Accession | F6TQW2]
Molecular Weight :
The protein has a predicted MW of 26.10 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse IgG2C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse IgG2C is greater than 95% as determined by SEC-HPLC.
Background :
Mouse IgG2c is a subclass of mouse antibody IgG, it can bind FcγRIV with high affinity and the Fc loop residues of mouse IgG2c promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
Synonyms :
Ighg2c; IgG2C
References & Citations :
(1) Falconer DJ, Barb AW. Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1. PLoS One. 2018 Feb 6;13(2):e0192123. doi: 10.1371/journal.pone.0192123. Erratum in: PLoS One. 2018 Apr 24;13(4):e0196609. PMID: 29408873; PMCID: PMC5800599.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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