Name : Mouse Activin RIIA/ACVR2A Protein
Product Source :
Recombinant Mouse Activin RIIA/ACVR2A Protein is expressed from HEK293 with His tag at the C-terminus. It contains Ala20-Pro135.[Accession | P27038]
Molecular Weight :
The protein has a predicted MW of 15.06 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse Activin RIIA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse Activin RIIA is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human Activin A, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Mouse Activin RIIA, His Tag with the EC50 of 0.13μg/ml determined by ELISA.
Background :
Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Synonyms :
ACTR-IIA; ACTRIIA; ACVR2A; ACVR2
References & Citations :
Zhuo C, Hu D, Li J, Yu H, Lin X, Chen Y, Zhuang Y, Li Q, Zheng X, Yang C. Downregulation of Activin A Receptor Type 2A Is Associated with Metastatic Potential and Poor Prognosis of Colon Cancer. J Cancer. 2018 Sep 8;9(19):3626-3633. doi: 10.7150/jca.26790. PMID: 30310521; PMCID: PMC6171025.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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