Name : Mouse IL-20RA Protein
Product Source :
Recombinant Mouse IL-20RA Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Val33-Lys253.[Accession | Q6PHB0]
Molecular Weight :
The protein has a predicted MW of 52.1 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse IL-20RA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SPR Data Mouse IL-20RA, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-20, His Tag with an affinity constant of 13.93 μM as determined in SPR assay (Biacore T200).
Background :
IL-20RA was highly expressed in the tumor tissue of CRC and related to the advanced stage.IL-20RA was involved in regulating oncogenic and immune pathways and affecting the expression of genes related to cell proliferation and immune evasion in CRC.Super-enhancer inhibition by JQ-1 or iBET-151 suppressed the growth of tumor cells and inhibited the expression of IL-20RA.
Synonyms :
IL-20R-alpha; IL-20RA; CRF2-8; IL-20R1; ZcytoR7; FLJ40993
References & Citations :
(1) Yu D, Yang X, Lin J, Cao Z, Lu C, Yang Z, Zheng M, Pan R, Cai W. Super-Enhancer Induced IL-20RA Promotes Proliferation/Metastasis and Immune Evasion in Colorectal Cancer. Front Oncol. 2021 Jul 15;11:724655. doi: 10.3389/fonc.2021.724655. PMID: 34336707; PMCID: PMC8319729.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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