Name : Human IL-3 R Beta/CD131 Protein
Product Source :
Recombinant Human IL-3 R Beta/CD131 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Thr17-Trp443.[Accession | P32927-1]
Molecular Weight :
The protein has a predicted MW of 50.30 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human IL-3 R Beta on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human IL-3 R Beta is greater than 95% as determined by SEC-HPLC.
Background :
Interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The beta c subunit does not bind any cytokine by itself but is involved in the formation of high-affinity functional receptors for IL-5 and GM-CSF. These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a distinct subfamily.
Synonyms :
CDw131; CD131; CSF2RB; IL3RB; IL5RB; AIC2A; Csfgmrb
References & Citations :
(1) Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF. Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding. Mol Cell Biol. 1996 Jun;16(6):3035-46. doi: 10.1128/MCB.16.6.3035. PMID: 8649415; PMCID: PMC231298.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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