Name : Mouse IL-3 R alpha/CD123 Protein
Product Source :
Recombinant Mouse IL-3 R alpha/CD123 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Ser17-Lys331.[Accession | P26952-1]
Molecular Weight :
The protein has a predicted MW of 36.12 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse IL-3 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse IL-3 R alpha is greater than 95% as determined by SEC-HPLC.
Background :
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
Synonyms :
CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; IL-3 R alpha
References & Citations :
(1)Ugo Testa, Elvira Pelosi, Arthur Frankel.CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies.Biomark Res. 2014; 2: 4
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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