Name : Cynomolgus IL-8/CXCL8 Protein
Product Source :
Recombinant Cynomolgus IL-8/CXCL8 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala23-Pro100.[Accession | A0A2K5TUL7]
Molecular Weight :
The protein has a predicted MW of 10.12 kDa. Due to glycosylation, the protein migrates to 12-14 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus IL-8 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. ELISA Data Immobilized Cynomolgus IL-8, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-IL-8 Antibody, hFc Tag with the EC50 of 13.0ng/ml determined by ELISA.
Background :
Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas.Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms.
Synonyms :
Interleukin-8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; GCP/IL-8 protein IV; IL8/NAP1 form I; CXCL8; LECT; LUCT; LYNAP; NAF
References & Citations :
(1) Kosmopoulos M, Christofides A, Drekolias D, Zavras PD, Gargalionis AN, Piperi C. Critical Role of IL-8 Targeting in Gliomas. Curr Med Chem. 2018;25(17):1954-1967. doi: 10.2174/0929867325666171129125712. PMID: 29189120.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
SVMP Protein
SARS-CoV-2 NSP7-NSP8 Heterodimer Protein (His)
Popular categories:
AKT Serine/Threonine Kinase 2 (AKT2)
FGF-16