Name : Human IL-17C Protein
Product Source :
Recombinant Human IL-17C Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains His19-Val197.[Accession | Q9P0M4]
Molecular Weight :
The protein has a predicted MW of 22.6 kDa. Due to glycosylation, the protein migrates to 25 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by SEC-HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in 50mM MES, 150mM NaCl (PH 6.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM MES, 150mM NaCl (PH 6.0).
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human IL-17C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SPR Data Human IL-17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-17C, His Tag with an affinity constant of 1.84 μM as determined in SPR assay (Biacore T200).
Background :
Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Synonyms :
CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884
References & Citations :
(1)Vandeghinste N , Klattig, Jürgen, Jagerschmidt C , et al. Neutralization of IL-17C reduces skin inflammation in mouse models of psoriasis and atopic dermatitis[J]. Journal of Investigative Dermatology, 2018:S0022202X1830126X.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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