Name : Human ASPH Protein
Product Source :
Recombinant Human ASPH Protein is expressed from E.coli with His tag at the N-Terminus. It contains Ile341-Ile758.[Accession | Q12797-1]
Molecular Weight :
The protein has a predicted MW of 49.2 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per ug by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ASPH on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human ASPH is greater than 95% as determined by SEC-HPLC.
Background :
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication.Expression profiling of Notch signaling components positively correlates with ASPH expression in breast cancer patients, confirming that ASPH-Notch axis acts functionally in breast tumorigenesis.
Synonyms :
Aspartate beta-hydroxylase; ASP beta-hydroxylase; Asph; Bah;Aspartate β-hydroxylase; ASP β-hydroxylase
References & Citations :
(1) Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Bai X, Sun B, Hung MC, Liu L, Wands J, Dong X. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019 Nov 7;18(1):156. doi: 10.1186/s12943-019-1077-0. PMID: 31694640; PMCID: PMC6836474.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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