Name : Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein
Product Source :
Recombinant Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe23-Ser1122(ITGA10)acidic tail & Gln21-Asp728(ITGB1)basic tail.[Accession | O75578-1(ITGA10)&P05556-1(ITGB1)]
Molecular Weight :
The protein has a predicted MW of 125.60 kDa (ITGA10) & 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA10) and 100-130 kDa (ITGB1) based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ITGA10&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
Alpha 10 beta 1 is currently known as four collagen-binding I domain-containing integrins, the others are namely alpha 1 beta 1, alpha 2 beta 1 and alpha 11 beta 1. α10β1 is likely to be expressed only by a subset offibroblasts.
Synonyms :
Integrin alpha 10 beta 1; ITGA10&ITGB1; α10β1
References & Citations :
Gullberg DE, Lundgren-Akerlund E. Collagen-binding I domain integrins–what do they do? Prog Histochem Cytochem. 2002;37(1):3-54. doi: 10.1016/s0079-6336(02)80008-0. PMID: 11876085.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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