Name : Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein
Product Source :
Recombinant Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe39-Leu1012(ITGA8) acidic tail & Gln21-Asp728(ITGB1) basic tail.[Accession | P53708(ITGA8)&P05556-1(ITGB1)]
Molecular Weight :
The protein has a predicted MW of 113.90 kDa (ITGA8) & 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 120-140 kDa (ITGA8) and 100-120 kDa (ITGB1) based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ITGA8&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Human Integrin alpha 8 beta 1 is a heterodimeric glycoprotein composed of integrin alpha 8 and integrin beta 1 that mainly expressed in smooth muscle cells. It functions as a receptor for Tenascin, Fibronectin, and Vitronectin and can promote attachment, cell spreading, and neurite outgrowth.
Synonyms :
ITGA8&ITGB1; ; α8β1; Integrin alpha 8 beta 1;
References & Citations :
[1] Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R. The human Integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995 Sep 29;270(39):23196-202.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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