Name : Human ITGB6 Protein
Product Source :
Recombinant Human ITGB6 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gly22-Asn707.[Accession | P18564-1]
Molecular Weight :
The protein has a predicted MW of 75.4 kDa. Due to glycosylation, the protein migrates to 80-115 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ITGB6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human ITGB6 is greater than 95% as determined by SEC-HPLC.
Background :
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5′ untranslated region (5’UTR) of the bovine ITGB6 gene.
Synonyms :
Integrin beta-6; Integrin beta 6; beta 6;Integrin β-6; Integrin β 6; β 6
References & Citations :
Singh R, Deb R, Singh U, Alex R, Kumar S, Chakraborti S, Sharma S, Sengar G, Singh R. Development of a tetra-primer ARMS PCR-based assay for detection of a novel single-nucleotide polymorphism in the 5′ untranslated region of the bovine ITGB6 receptor gene associated with foot-and-mouth disease susceptibility in cattle. Arch Virol. 2014 Dec;159(12):3385-9. doi: 10.1007/s00705-014-2194-0. Epub 2014 Jul 31. PMID: 25078391.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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