Name : Human B2M/beta 2-Microglobulin Protein
Product Source :
Recombinant Human B2M/beta 2-Microglobulin Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Ile21-Met119.[Accession | P61769-1]
Molecular Weight :
The protein has a predicted MW of 38.4 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human B2M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human B2M is greater than 95% as determined by SEC-HPLC.
Background :
To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly higher than that found in normal synovial fluid. B2M is highly expressed in OA cartilage and synovial fluid compared to normal, and suggest that B2M may have effects on chondrocyte function that could contribute to OA pathogenesis.
Synonyms :
Beta-2-microglobulin;B2M;β-2-microglobulin
References & Citations :
(1) Zhang H, Liew CC, Marshall KW. Microarray analysis reveals the involvement of beta-2 microglobulin (B2M) in human osteoarthritis. Osteoarthritis Cartilage. 2002 Dec;10(12):950-60. doi: 10.1053/joca.2002.0850. PMID: 12464555.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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