Name : Mouse LGMN Protein
Product Source :
Recombinant Mouse LGMN Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Val18-Tyr435.[Accession | O89017]
Molecular Weight :
The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse LGMN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse LGMN is greater than 95% as determined by SEC-HPLC.
Background :
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer’s disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
Synonyms :
Legumain; Prsc1; AEP; LGMN; LGMN1; AI746452; AU022324
References & Citations :
(1) Zhang X, Jiao B, Weng L, Zhou Y, Guo L, Wang X, Zhou L, Liu X, Xiao X, Liu H, Zhu X, Li C, Zhu Y, Yang Q, Lin Z, Jiang Y, Wen Y, Zhou H, Shen L, Liao X. Lack of association between LGMN and Alzheimer’s disease in the Southern Han Chinese population. Eur J Neurosci. 2020 Oct;52(8):4009-4017. doi: 10.1111/ejn.14857. Epub 2020 Jun 28. PMID: 32506655.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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