Name : Human LGR-4 Protein
Product Source :
Recombinant Human LGR-4 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Leu28–Leu396.[Accession | Q9BXB1-1]
Molecular Weight :
The protein has a predicted MW of 50.20 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human LGR-4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human LGR-4 is greater than 95% as determined by SEC-HPLC. SPR Data Human R Spondin 3, His Tag immobilized on CM5 Chip can bind Human LGR4, His Tag with an affinity constant of 0.440 μM as determined in SPR assay (Biacore T200).
Background :
Leucine-rich repeat-containing G protein-coupled receptor (LGR)-4 is a G protein-coupled receptor (GPCR) with a seven-transmembrane domain structure. LGRs are evolutionally and structurally phylogenetic, classified into three subgroups and are members of the so-called orphan receptors.
Synonyms :
LGR4; GPR48
References & Citations :
Kato S, Matsubara M, Matsuo T, Mohri Y, Kazama I, Hatano R, Umezawa A, Nishimori K. Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 2006;104(2):e63-75. doi: 10.1159/000093999. Epub 2006 Jun 19. PMID: 16785743.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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