Name : Biotinylated Human LILRA6/CD85b/ILT8 Protein
Product Source :
Recombinant Biotinylated Human LILRA6/CD85b/ILT8 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gly24-Asn447.[Accession | Q6PI73-1]
Molecular Weight :
The protein has a predicted MW of 49.2 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Human LILRA6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Biotinylated Human LILRA6 is greater than 95% as determined by SEC-HPLC.
Background :
The LILRs are a family of receptors that regulate the activities of myelomonocytic cells. Specific allelic variants of two related members of the LILR family, LILRB3 and LILRA6, interact with a ligand exposed on necrotic glandular epithelial cells. The extracellular domains of LILRB3 and LILRA6 are very similar and their genes are highly polymorphic.
Synonyms :
7M1; CD85b; ILT8; LILRA6; Pira3
References & Citations :
(1) Jones DC, Hewitt CR, López-Álvarez MR, Jahnke M, Russell AI, Radjabova V, Trowsdale AR, Trowsdale J. Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8-associated ligand on necrotic glandular epithelial cells. Oncotarget. 2016 Mar 29;7(13):15618-31. doi: 10.18632/oncotarget.6905. PMID: 26769854; PMCID: PMC4941265.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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