Name : Cynomolgus LRIG1 Protein
Product Source :
Recombinant Cynomolgus LRIG1 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ala34-Thr792.[Accession | A0A2K5V8J9]
Molecular Weight :
The protein has a predicted MW of 84.16 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus LRIG1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. ELISA Data Immobilized Cynomolgus LRIG1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-LRIG1 Antibody, hFc Tag with the EC50 of 11.6ng/ml determined by ELISA.
Background :
The leucine-rich repeats and immunoglobulin-like domains (LRIG)-1 is a tumor suppressor gene that belongs to the LRIG family. LRIG1 expression has prognostic significance in various human cancers. Somatic mutations, which are associated with a certain rate of response to targeted therapies, are ubiquitously found in human non-small cell lung cancer (NSCLC). LRIG1 was an independent prognostic factor for OS of NSCLC patients. LRIG1 in combination with other clinicopathological risk factors was a stronger prognostic model than clinicopathological risk factors alone.
Synonyms :
LIG-1; LIG1; LRIG1; D6Bwg0781e; Img
References & Citations :
(1) An Y, Zhao Z, Ou P, Wang G. Expression of LRIG1 is Associated With Good Prognosis for Human Non-small Cell Lung Cancer. Medicine (Baltimore). 2015 Nov;94(47):e2081. doi: 10.1097/MD.0000000000002081. PMID: 26632716; PMCID: PMC5058985.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
XIAP Protein
USP28 Protein
Popular categories:
Fc Receptor-like A
DENV Non-structural Protein 1 (NS1)