Name : Human MBL2/Mannan Binding Lectin Protein
Product Source :
Recombinant Human MBL2/Mannan Binding Lectin Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Glu21-Ile248.[Accession | P11226]
Molecular Weight :
The protein has a predicted MW of 25.11 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human MBL2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation.It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms.
Synonyms :
MBP-C; MBPC; MBL2; Mannan Binding Lectin; Collectin-1; MBP1; COLEC1; MBL;HSMBPC; MBL2D; MBPD
References & Citations :
(1) Dong L, Wu J, Chen K, Xie J, Wang Y, Li D, Liu Y, Yin A, Zhao Y, Han Y, Zhou J, Zhang L, Chen Z, Zuo D. Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis. Front Immunol. 2019 Jun 4;10:1239. doi: 10.3389/fimmu.2019.01239. PMID: 31214191; PMCID: PMC6557994.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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