Name : Human MD2 Protein
Product Source :
Recombinant Human MD2 Protein is expressed from E.coli with His tag at the C-Terminus. It contains Gln19-Asn160.[Accession | Q9Y6Y9-1]
Molecular Weight :
The protein has a predicted MW of 18.07 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in 4mM HCL. Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 4mM HCL.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human MD2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host.
Synonyms :
Lymphocyte antigen 96; LY96; Ly-96; ESOP1; ESOP-1; MD-2;
References & Citations :
Tandon A, Harioudh MK, Ishrat N, Tripathi AK, Srivastava S, Ghosh JK. An MD2-derived peptide promotes LPS aggregation, facilitates its internalization in THP-1 cells, and inhibits LPS-induced pro-inflammatory responses. Cell Mol Life Sci. 2018 Jul;75(13):2431-2446. doi: 10.1007/s00018-017-2735-2. Epub 2018 Jan 8. PMID: 29313060.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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