Name : Cynomolgus MERTK/Mer Protein
Product Source :
Recombinant Cynomolgus MERTK/Mer Protein is expressed from HEK293 with His tag at the C-terminus. It contains Ala23-Ile507.[Accession | XP_005575320.2]
Molecular Weight :
The protein has a predicted MW of 53.85 kDa. Due to glycosylation, the protein migrates to 58-115 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus MERTK on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus MERTK is greater than 95% as determined by SEC-HPLC.
Background :
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.
Synonyms :
MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12
References & Citations :
(1)Wu J, Frady LN, Bash RE, Cohen SM, Schorzman AN, Su YT, Irvin DM, Zamboni WC, Wang X, Frye SV, Ewend MG, Sulman EP, Gilbert MR, Earp HS, Miller CR. MerTK as a therapeutic target in glioblastoma. Neuro Oncol. 2018 Jan 10;20(1):92-102. doi: 10.1093/neuonc/nox111. PMID: 28605477; PMCID: PMC5761530.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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