Name : Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer Protein
Product Source :
Recombinant Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer Protein is expressed from HEK293 with His tag at the C-terminus. It contains Gly25-Thr206 (Human HLA-A*02:01 α1&α2) and Asp207-Glu299 (Mouse H-2Ld α3), Ile21-Met119 (mB2M) and KVAELVHFL peptide.[Accession | A0A140T913(Human HLA-A*02:01 α1&α2)&P01897(Mouse H-2Ld α3)&P01887(Mouse B2M)&KVAELVHFL]
Molecular Weight :
The protein has a predicted MW of 48.00 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer is greater than 95% as determined by SEC-HPLC.
Background :
Melanoma antigen family A, 3 (MAGE-A3) is a cancer-testis antigen whose expression has been demonstrated in a wide array of malignancies including melanoma, brain, breast, lung and ovarian cancer. In addition, its ability to elicit spontaneous humoral and cellular immune responses has been shown in cancer patients.
Synonyms :
MAGE-A3
References & Citations :
Esfandiary A, Ghafouri-Fard S. MAGE-A3: an immunogenic target used in clinical practice. Immunotherapy. 2015;7(6):683-704. doi: 10.2217/imt.15.29. Epub 2015 Jun 23. PMID: 26100270.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Semaphorin-7A/SEMA7A Protein
I-TAC/CXCL11 Protein
Popular categories:
ADAMTSL-1/Punctin-1
AKT Serine/Threonine Kinase 1 (AKT1)