Name : Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Monomer Protein
Product Source :
Recombinant Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and GLYDGMEHL peptide.[Accession | A0A140T913(HLA-A*02:01)&P61769(B2M)&GLYDGMEHL]
Molecular Weight :
The protein has a predicted MW of 50.44 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human HLA-A*02:01&B2M&MAGE-A10 (GLYDGMEHL) Monomer is greater than 95% as determined by SEC-HPLC.
Background :
MAGE-A10 is a subtype of the Melanoma-associated antigen A (MAGE-A), a class of tumor antigens that are extensively expressed in various histological types of tumors and represents an attractive target for tumor immunotherapy. High-level expression of MAGE-A10 improved the anti-tumor immune cytotoxicity of MAGE-A10-specific CTLs in lung cancer cell lines and primary lung cancer cells.
Synonyms :
MAGE-A10
References & Citations :
Li Z, Guo P, Guo P, Dong K, Liu F, Wu Y, Li J, Shan B, Sang M. 5-aza-2′-deoxycytidine (DAC) treatment induces the MAGE-A10 expression and improves the cytotoxicity of MAGE-A10-specific CTLs in lung cancer cells. Transl Cancer Res. 2020 Feb;9(2):1235-1245. doi: 10.21037/tcr.2020.01.10. PMID: 35117468; PMCID: PMC8798493.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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