Name : Mouse Midkine Protein
Product Source :
Recombinant Mouse Midkine Protein is expressed from E.coli with His tag at the N-Terminus. It contains Lys23-Asp140.[Accession | P12025]
Molecular Weight :
The protein has a predicted MW of 14.03 kDa. The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in PBS, 350mM NaCl, 200mM L-arginine (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse Midkine on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis.
Synonyms :
MK; ARAP; MDK; MEK; MK1; MKARAP; NEGF2
References & Citations :
Filippou PS, Karagiannis GS, Constantinidou A. Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target. Oncogene. 2020 Mar;39(10):2040-2054. doi: 10.1038/s41388-019-1124-8. Epub 2019 Dec 4. PMID: 31801970.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Animal-Free IL-26/AK155 Protein
B18R Protein
Popular categories:
E-Selectin/CD62E
CD171/L1CAM