Name : Human MRC2 Protein
Product Source :
Recombinant Human MRC2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gly31-Pro530.[Accession | Q9UBG0]
Molecular Weight :
The protein has a predicted MW of 57.64 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human MRC2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human MRC2 is greater than 95% as determined by SEC-HPLC.
Background :
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the Mannose Receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis.
Synonyms :
C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage Mannose Receptor 2, Urokinase-type plasminogen activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)
References & Citations :
(1) Gai X, Tu K, Lu Z, Zheng X. MRC2 expression correlates with TGFβ1 and survival in hepatocellular carcinoma. Int J Mol Sci. 2014 Aug 26;15(9):15011-25. doi: 10.3390/ijms150915011. PMID: 25162823; PMCID: PMC4200867.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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