Name : Mouse MARCO Protein
Product Source :
Recombinant Mouse MARCO Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Gln70-Ser518.[Accession | Q60754-1]
Molecular Weight :
The protein has a predicted MW of 46.2 kDa. Due to glycosylation, the protein migrates to 48-53 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse MARCO on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse MARCO is greater than 95% as determined by SEC-HPLC.
Background :
Scavenger receptor A5 (SCARA5) is a member of the class A scavenger receptors, with most similarity to SCARA1 (SR-A) and SCARA2 (MARCO), which are primarily expressed by macrophages and dendritic cells, in which they participate in clearance of various polyanionic macromolecules, pollution particles, and pathogens.In contrast to expression of SCARA1 and SCARA2 in immune cells, SCARA5 is found in a subset of fibroblast-like cells in the interstitial stroma of most organs, with additional expression in the epithelial cells of testis and choroid plexus
Synonyms :
MARCO; SCARA2; AI323439; Ly112
References & Citations :
(1) Ojala JR, Pikkarainen T, Elmberger G, Tryggvason K. Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice. Am J Pathol. 2013 May;182(5):1681-95. doi: 10.1016/j.ajpath.2013.01.042. Epub 2013 Mar 15. PMID: 23499552.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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