Name : Human Nectin-1/PVRL1/CD111 Protein
Product Source :
Recombinant Human Nectin-1/PVRL1/CD111 Protein is expressed from HEK293 with hFc tag at the C-terminus. It contains Gln31-Thr334.[Accession | Q15223-1]
Molecular Weight :
The protein has a predicted MW of 59.89 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Nectin-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human Nectin-1 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human Nectin-3, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human Nectin-1, hFc Tag with the EC50 of 19.6ng/ml determined by ELISA (QC Test). ELISA Data Immobilized Human Nectin-4, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human Nectin-1, hFc Tag with the EC50 of 0.27μg/ml determined by ELISA.
Background :
Nectins are a small family of Ca -independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that organize intercellular junctions. They are highly homologous to the human receptor for poliovirus, and as such have been alternately named poliovirus receptor-related proteins.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Has some neurite outgrowth-promoting activity.
Synonyms :
CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR
References & Citations :
(1)Yu Z , Adusumilli P S , Eisenberg D P , et al. Nectin-1 Expression by Squamous Cell Carcinoma is a Predictor of Herpes Oncolytic Sensitivity[J]. Molecular Therapy, 2007, 15(1):103-113.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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