Name : Human Beta-NGF Protein
Product Source :
Recombinant Human Beta-NGF Protein is expressed from HEK293 without tag. It contains Ser122-Ala241.[Accession | P01138]
Molecular Weight :
The protein has a predicted MW of 13.49 kDa. Due to glycosylation, the protein migrates to 14-18 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22 μm filtered solution in 20mM NaAc, 150mM Nacl (pH 5.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Beta-NGF on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. Cell Based Assay Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2 – 2 ng/ml.
Background :
Nerve growth factor-beta (β-NGF) is a polypeptide growth factor that regulates survival, growth, and differentiation of specific peripheral and central neurons via its high-affinity receptor, tyrosine kinase receptor A (TrKA), and low-affinity receptor, p75 neurotrophin receptor (p75NTR).
Synonyms :
NGF; NGFB; Beta NGF; HSAN5;
References & Citations :
Sari LM, Zampini R, Argañaraz ME, Carretero MI, Fumuso FG, Barraza DE, Ratto M, Apichela SA. Expression of β-NGF and high-affinity NGF receptor (TrKA) in llama (Lama glama) male reproductive tract and spermatozoa. Mol Reprod Dev. 2018 Dec;85(12):934-944. doi: 10.1002/mrd.23075. Epub 2018 Nov 14. PMID: 30328213.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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