Name : Cynomolgus NKG2C/CD159c Protein
Product Source :
Recombinant Cynomolgus NKG2C/CD159c Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Ile94-Leu231.[Accession | Q68VD0-1]
Molecular Weight :
The protein has a predicted MW of 16.9 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus NKG2C/CD159c on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
Background :
As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role in biasing adaptive immune responses upon influenza vaccination and suggests NKG2C as a potential biomarker in predicting pandemic influenza vaccine responsiveness.
Synonyms :
CD159c; KLRC2; NKG2C; NK cell receptor C
References & Citations :
(1) Riese P, Trittel S, Pathirana RD, Klawonn F, Cox RJ, Guzmán CA. Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells. Vaccines (Basel). 2020 Jun 5;8(2):281. doi: 10.3390/vaccines8020281. PMID: 32517137; PMCID: PMC7349951.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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