Name : Cynomolgus NOGOR Protein
Product Source :
Recombinant Cynomolgus NOGOR Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Cys27-Ser447.[Accession | Q9N0E3]
Molecular Weight :
The protein has a predicted MW of 46.34 kDa. Due to glycosylation, the protein migrates to 60-73 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 90% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Cynomolgus NOGOR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Cynomolgus NOGOR is greater than 90% as determined by SEC-HPLC. ELISA Data Immobilized Cynomolgus NOGOR, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-NOGOR Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA.
Background :
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes.
Synonyms :
Nogo receptor; RTN4R; NOGOR; NgR1; Nogo-66 receptor; NGR
References & Citations :
(1) Hsu R, Woodroffe A, Lai WS, Cook MN, Mukai J, Dunning JP, Swanson DJ, Roos JL, Abecasis GR, Karayiorgou M, Gogos JA. Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. PLoS One. 2007 Nov 28;2(11):e1234. doi: 10.1371/journal.pone.0001234. PMID: 18043741; PMCID: PMC2077930.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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