Name : Human Neuropilin-2 Protein
Product Source :
Recombinant Human Neuropilin-2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln23-Pro859.[Accession | NP_003863.2]
Molecular Weight :
The protein has a predicted MW of 95.4 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Neuropilin-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human Neuropilin-2 is greater than 95% as determined by SEC-HPLC.
Background :
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells.
Synonyms :
Neuropilin-2; NRP2; VEGF165R2; NP2; NPN2; PRO2714
References & Citations :
(1) Schellenburg S, Schulz A, Poitz DM, Muders MH. Role of neuropilin-2 in the immune system. Mol Immunol. 2017 Oct;90:239-244. doi: 10.1016/j.molimm.2017.08.010. Epub 2017 Aug 30. PMID: 28843905.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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