Name : Human Osteomodulin Protein
Product Source :
Recombinant Human Osteomodulin Protein is expressed from HEK293 with His tag at the C-terminus. It contains Gln21-Glu421.[Accession | Q99983]
Molecular Weight :
The protein has a predicted MW of 48.25 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Osteomodulin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Osteomodulin (OMD) is a member of the small leucine-rich repeat proteoglycan family, which is involved in the organization of the extracellular matrix. OMD is located in bone tissue and is reportedly important for bone mineralization. Mechanistically, OMD could bind to BMP2 via its terminal leucine-rich repeats and formed complexes with BMP2 and its membrane receptors, thus promoting BMP/SMAD signal transduction. In addition, OMD was a putative target gene of SMAD4, which plays a pivotal role in this pathway.
Synonyms :
OSAD; OMD; SLRR2C
References & Citations :
(1) Tashima T, Nagatoishi S, Sagara H, Ohnuma S, Tsumoto K. Osteomodulin regulates diameter and alters shape of collagen fibrils. Biochem Biophys Res Commun. 2015 Jul 31;463(3):292-6. doi: 10.1016/j.bbrc.2015.05.053. Epub 2015 May 20. PMID: 26003732.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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