Name : Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling)
Product Source :
Recombinant Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling) is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Pro663.[Accession | A0A2K5USI5]
Molecular Weight :
The protein has a predicted MW of 76.6 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol, 0.5mM TCEP, 1mM EDTA (pH 8.0).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Biotinylated Cynomolgus PADI4 (Primary Amine Labeling) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.
Synonyms :
Protein-arginine deiminase type-4; HL-60 PAD; HL60 PAD; HL-60; PAD; PAD4; PADI5; PDI5
References & Citations :
Seri Y, Shoda H, Matsumoto I, Sumida T, Fujio K, Yamamoto K. [Peptidylarginine deiminase type4 (PADI4) role in immune system]. Nihon Rinsho Meneki Gakkai Kaishi. 2014;37(3):154-9. Japanese. doi: 10.2177/jsci.37.154. PMID: 24974927.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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