Name : Human PRL-3/PTP4A3 Protein
Product Source :
Recombinant Human PRL-3/PTP4A3 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Cys170.[Accession | O75365-1]
Molecular Weight :
The protein has a predicted MW of 20.29 kDa same as Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 20mM PB, 500mM NaCl, 2mM DTT, 20% Glycerol (pH 7.5).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PRL-3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human PRL-3 is greater than 95% as determined by SEC-HPLC. Bioactivity Data Measured by its ability to cleave a substrate. p-Nitrophenvl phosphate (pNPP). The specific activity is > 0.5 pmol/min/μg.
Background :
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors.
Synonyms :
PRL-R; PRLR; PRL-3; PRL3; PTP4A3;
References & Citations :
(1) Hardy S, Kostantin E, Wang SJ, Hristova T, Galicia-Vázquez G, Baranov PV, Pelletier J, Tremblay ML. Magnesium-sensitive upstream ORF controls PRL Phosphatase expression to mediate energy metabolism. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4. PMID: 30718434; PMCID: PMC6386685.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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