Name : Cynomolgus PS20 Protein

Product Source :
Recombinant Cynomolgus PS20 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Lys32-Gln192.[Accession | XP_015298715.2]

Molecular Weight :
The protein has a predicted MW of 18.77 kDa. The protein migrates to 25-28 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE

Formulation :
Supplied as 0.22μm filtered solution in 20mM PB, 500mM NaCl, 200mM Arginine (pH 7.4).

Reconstitution :

Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Cynomolgus PS20 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Background :
The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20(-/-) compared to ps20(/) mice. Roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to MHV-1 infection.

Synonyms :
Ps20; Wfdc1

References & Citations :
(1) Rogers E, Wang BX, Cui Z, Rowley DR, Ressler SJ, Vyakarnam A, Fish EN. WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection. Antiviral Res. 2012 Nov;96(2):158-68. doi: 10.1016/j.antiviral.2012.08.012. Epub 2012 Sep 6. PMID: 22960155; PMCID: PMC7114264.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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