Name : Human PTP alpha/PTPRA Protein
Product Source :
Recombinant Human PTP alpha/PTPRA Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus. It contains Ala183-Lys802.[Accession | P18433-5]
Molecular Weight :
The protein has a predicted MW of 73.00 kDa. The protein migrates to 68-75 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 20% glycerol, 3mM DTT (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human PTP alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
The receptor protein-tyrosine phosphatase α (encoded by PTPRA), a 130-kDa transmembrane PTP, has shown to be a physiological regulator for PTK c-Src and the kinases involved in integrin signaling pathway including FAK and P130cas. The activation of PTPRA on Src Y530 dephosphorylation led to cellular transformation, which suggested that PTPRA might be an oncogenic gene.
Synonyms :
R-PTP-alpha; PTPRA; PTPA; PTPRL2; PTP alpha; HEPTP; HLPR; HPTPA;
References & Citations :
Gu Z, Fang X, Li C, Chen C, Liang G, Zheng X, Fan Q. Increased PTPRA expression leads to poor prognosis through c-Src activation and G1 phase progression in squamous cell lung cancer. Int J Oncol. 2017 Aug;51(2):489-497. doi: 10.3892/ijo.2017.4055. Epub 2017 Jun 23. PMID: 28656243; PMCID: PMC5505127.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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