Name : Human ROR1 Protein
Product Source :
Recombinant Human ROR1 Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus. It contains Met453-Asn783.[Accession | AAA60275.1]
Molecular Weight :
The protein has a predicted MW of 39.21 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 2mM GSH, 3mM DTT, 10% glycerol (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ROR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SPR Data Anti-ROR1 Antibody, hFc Tag captured on CM5 Chip via Protein A can bind Human ROR1, His Tag with an affinity constant of 26.40 nM as determined in SPR assay (Biacore T200).
Background :
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family receptor tyrosine kinases, and by the extracellular Frizzled-like cysteine-rich domains and kringle domains, which are common to receptors of the Wnt family members.
Synonyms :
ROR1; NTRKR1; dJ537F10.1
References & Citations :
(1)Zhang S , Cui B , Lai H , et al. Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy[J]. Proceedings of the National Academy of Sciences, 2014, 111(48):17266-71.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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