Name : Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) Protein
Product Source :
Recombinant Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Glu165-Asp305.[Accession | Q01973-1]
Molecular Weight :
The protein has a predicted MW of 17 kDa. Due to glycosylation, the protein migrates to 18-24 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) is greater than 95% as determined by SEC-HPLC.
Background :
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family receptor tyrosine kinases, and by the extracellular Frizzled-like cysteine-rich domains and kringle domains, which are common to receptors of the Wnt family members.
Synonyms :
ROR1; NTRKR1; dJ537F10.1
References & Citations :
(1)Zhang S , Cui B , Lai H , et al. Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy[J]. Proceedings of the National Academy of Sciences, 2014, 111(48):17266-71.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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