Name : Human ROR2/NTRKR2 Protein
Product Source :
Recombinant Human ROR2/NTRKR2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Val34-Gly403.[Accession | A1L4F5]
Molecular Weight :
The protein has a predicted MW of 44.2 kDa. Due to glycosylation, the protein migrates to 54-58 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human ROR2 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%. SEC-HPLC The purity of Human ROR2 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human ROR2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-ROR2 Antibody, hFc Tag with the EC50 of 3.6ng/ml determined by ELISA.
Background :
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. Mature human ROR2 contains a 369 amino acid (aa) extracellular domain (ECD) and a 518 aa cytoplasmic tail containing an tyrosine kinase domain.
Synonyms :
BDB; BDB1; NTRKR2; ROR2
References & Citations :
(1)Debebe Z , Rathmell W K. Ror2 as a Therapeutic Target in Cancer[J]. Pharmacology & Therapeutics, 2015, 150:143-148.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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