Name : Human Pentraxin 2/SAP Protein
Product Source :
Recombinant Human Pentraxin 2/SAP Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains His20-Val223.[Accession | P02743]
Molecular Weight :
The protein has a predicted MW of 50 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Pentraxin 2/SAP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. ELISA Data Immobilized Human Pentraxin 2, hFc Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Anti-Pentraxin 2 Antibody, hFc Tag with the EC50 54.5ng/ml determined by ELISA.
Background :
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases.
Synonyms :
SAP; APCS; MGC88159; Pentraxin 2; PTX2
References & Citations :
(1) Nakagawa N, Barron L, Gomez IG, Johnson BG, Roach AM, Kameoka S, Jack RM, Lupher ML Jr, Gharib SA, Duffield JS. Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease. JCI Insight. 2016 Dec 8;1(20):e87446. doi: 10.1172/jci.insight.87446. PMID: 27942582; PMCID: PMC5135274.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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