Name : Human SEZ6L2 Protein
Product Source :
Recombinant Human SEZ6L2 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Leu28-Asn844.[Accession | Q6UXD5-1]
Molecular Weight :
The protein has a predicted MW of 88.5 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human SEZ6L2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human SEZ6L2 is greater than 95% as determined by SEC-HPLC.
Background :
Seizure-related 6 homolog (mouse)-like 2 (SEZ6L2) was shown to be involved in transcription of a type 1 transmembrane protein for regulating cell fate. SEZ6L2 was significantly up-regulated in tumour tissues of patients with CRC compared with adjacent normal tissues. Up-regulation of SEZ6L2 was correlated with a poor prognosis in patients with CRC. Furthermore, SEZ6L2 expression was inversely correlated with the expression of cytochrome C in malignant tissues in patients with CRC.
Synonyms :
BSRP-A; PSK-1; SEZ6L2; UNQ1903/PRO4349
References & Citations :
(1) An N, Zhao Y, Lan H, Zhang M, Yin Y, Yi C. SEZ6L2 knockdown impairs tumour growth by promoting caspase-dependent apoptosis in colorectal cancer. J Cell Mol Med. 2020 Apr;24(7):4223-4232. doi: 10.1111/jcmm.15082. Epub 2020 Feb 27. PMID: 32105413; PMCID: PMC7171412.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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