Name : Mouse Serpin F1/PEDF Protein

Product Source :
Recombinant Mouse Serpin F1/PEDF Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln20-Thr417.[Accession | P97298]

Molecular Weight :
The protein has a predicted MW of 45.4 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl (pH 8.0).

Reconstitution :

Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Mouse Serpin F1/PEDF on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse Serpin F1/PEDF is greater than 95% as determined by SEC-HPLC.

Background :
Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis.

Synonyms :
PEDF; EPC-1; Serpin F1; SERPINF1; PIG35

References & Citations :
(1) Ansari D, Althini C, Ohlsson H, Bauden M, Andersson R. The Role of PEDF in Pancreatic Cancer. Anticancer Res. 2019 Jul;39(7):3311-3315. doi: 10.21873/anticanres.13473. PMID: 31262851.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
TGF-beta 1 ProteinFormulation
Animal-Free GM-CSF Proteinsupplier
Popular categories:
NT-4/5
M-CSF R