Name : Human SLAMF6/NTB-A Protein
Product Source :
Recombinant Human SLAMF6/NTB-A Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gln22-Met226.[Accession | Q96DU3-1]
Molecular Weight :
The protein has a predicted MW of 26 kDa. Due to glycosylation, the protein migrates to 35-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human SLAMF6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human SLAMF6 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized Human SLAMF6, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-SLAMF6 Antibody, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA.
Background :
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2.
Synonyms :
ANK-T-B-antigen; NTB-A; CD352; SLAMF6; KALI; Ly108; NK-T-B-antigen; KALIb; SF2000
References & Citations :
(1) Dragovich MA, Adam K, Strazza M, Tocheva AS, Peled M, Mor A. SLAMF6 clustering is required to augment T cell activation. PLoS One. 2019 Jun 14;14(6):e0218109. doi: 10.1371/journal.pone.0218109. PMID: 31199820; PMCID: PMC6568412.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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