Name : Mouse CSPG5 Protein
Product Source :
Recombinant Mouse CSPG5 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Val31-Cys423.[Accession | AAH55736]
Molecular Weight :
The protein has a predicted MW of 42.69 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse CSPG5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse CSPG5 is greater than 95% as determined by SEC-HPLC.
Background :
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells.
Synonyms :
Chondroitin sulfate proteoglycan 5;Cspg5;Caleb;Ngc; CALEB;MGC44034;Neuroglycan C;NGC
References & Citations :
(1) Jüttner R, Montag D, Craveiro RB, Babich A, Vetter P, Rathjen FG. Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C). Eur J Neurosci. 2013 Nov;38(9):3270-80. doi: 10.1111/ejn.12313. Epub 2013 Jul 25. PMID: 23889129.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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