Name : Human SR-BI/SCARB1 Protein
Product Source :
Recombinant Human SR-BI/SCARB1 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Pro33-Tyr443.[Accession | Q8WTV0-1]
Molecular Weight :
The protein has a predicted MW of 47.76 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 90% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human SR-BI on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human SR-BI is greater than 90% as determined by SEC-HPLC.
Background :
The scavenger receptor class B member 1 (SR-B1 or Scarb1) is a glycosylated cell surface receptor for high density lipoproteins (HDL), oxidized low density lipoproteins (OxLDL), and phosphocholine-containing oxidized phospholipids (PC-OxPLs). Scarb1 is expressed in macrophages and has been shown to have both pro- and anti-atherogenic properties.
Synonyms :
SRB1; SR-BI; SCARB1; CLA-1; CLA1; CD36; CD36L1; HDLQTL6
References & Citations :
Palmieri M, Joseph TE, O’Brien CA, Gomez-Acevedo H, Kim HN, Manolagas SC, Ambrogini E. RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass. Bone. 2023 May;170:116702. doi: 10.1016/j.bone.2023.116702. Epub 2023 Feb 10. Retraction in: Bone. 2023 Aug 24;176:116885. PMID: 36773885; PMCID: PMC10040251.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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