Name : Human ST3GAL4 Protein

Product Source :
Recombinant Human ST3GAL4 Protein is expressed from HEK293 with His tag at the C-Terminus and HA at the N-Terminus. It contains Glu41-Phe333.[Accession | Q11206.1]

Molecular Weight :
The protein has a predicted MW of 35.4 kDa. Due to glycosylation, the protein migrates to 48-53 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE

Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human ST3GAL4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Background :
ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x).

Synonyms :
SIAT4; SIAT4C; ST3GAL4; ST3GalA.2; ST-4; STZSIAT4; CGS23; Gal-NAc 6S; NANTA3; SAT3; SAT-3

References & Citations :
(1) Roa-de La Cruz L, Martínez-Morales P, Morán-Cruz I, Milflores-Flores L, Rosas-Murrieta N, González-Ramírez C, Ortiz-Mateos C, Monterrosas-Santamaría R, González-Frías C, Rodea-Ávila C, Apresa-García T, Aguilar-Lemarroy A, Jave-Suarez L, Santos-López G, Reyes-Leyva J, Vallejo-Ruiz V. Expression analysis of ST3GAL4 transcripts in cervical cancer cells. Mol Med Rep. 2018 Jul;18(1):617-621. doi: 10.3892/mmr.2018.8938. Epub 2018 Apr 27. PMID: 29749491.

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