Name : Human TFF1 Protein
Product Source :
Recombinant Human TFF1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Glu25-Phe84.[Accession | P04155]
Molecular Weight :
The protein has a predicted MW of 33.3 kDa. Due to glycosylation, the protein migrates to 40-45 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human TFF1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human TFF1 is greater than 95% as determined by SEC-HPLC.
Background :
Breast cancer (BC) is the most common cancer in women and the second leading cause of their cancer death. Establishing an accurate BC prognosis is very difficult because of its heterogeneity. Elevated TFF1 levels in serum were associated with development of BC, TFF1 expression was upregulated in BC compared to the healthy breast tissue.That expression of TFF1 was related to ER status of BC and that expression of TFF1 was lower in TNBC than in non-TNBC.
Synonyms :
Trefoil factor 1; Bcei; BCEI; D21S21; HP1.A; HPS2; pNR-2; Polypeptide P1.A; PS2; TFF1
References & Citations :
(1) Yi J, Ren L, Li D, Wu J, Li W, Du G, Wang J. Trefoil factor 1 (TFF1) is a potential prognostic biomarker with functional significance in breast cancers. Biomed Pharmacother. 2020 Apr;124:109827. doi: 10.1016/j.biopha.2020.109827. Epub 2020 Jan 24. PMID: 31986408.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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